DEVELOPMENT AND EVALUATION OF MICROEMULSION FORMULATIONS OF LORNOXICAM

Background and aims: Microemulsions (ME) basically are the mixture of oil, surfactant (SA) water, with a co (Co-SA) in different ratio. This is clear stable. The final prepared fluid possesses low viscosity. ME isotropic, stable transparent systems droplets diameter>500 nm. Due to small size, they may serve an excellent carrier for drugs having poor water solubility. Lornoxicam derivative allylamine, used orally treatment hepatic failure, neutropenia. Methods: In present study attempt was made increase solubility by means formulations. Oil, co-surfactant were selected based on their criteria. Total 5 formulations developed using titration method. Prepared evaluated parameters. Results: percent transmission found be range 98.48±0.15to 99.42±0.04. Refractive index micro emulsion 1.3218±0.009 1.3720±0.021. Percent drug content 98.47±0.08 99.75±0.21. ME5 has shown faster release 91.2±0.06% in-vitro 4 hrs. Conclusion: Study concluded that microemulsions can enhanced. Peer Review History: Received: 15 November 2022; Revised: 8 December; Accepted: 9 January 2023, Available online: 2023 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University Alexandria, Egypt, [email protected] Received file: Reviewer's Comments: Average review marks at initial stage: 6.0/10 publication 7.5/10 Reviewers: Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, [email protected] George Zhu, Tehran Medical Sciences, Tehran, Iran, [email protected] Similar Articles: FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL TERBINAFINE